New Antiviral Treatments To Be Trialled In Derbyshire
Local GPs and healthcare professionals are soon to begin enrolling participants across Derbyshire to a first-of-its-kind clinical trial investigating the effectiveness of new oral antiviral treatments for COVID-19 - which can be safely taken at home.
The Platform Adaptive trial of NOvel antiviRals for eArly treatMent of covid-19 In the Community (PANORAMIC) trial will rapidly assess a range of purpose-designed antiviral treatments. These treatments could help clinically vulnerable people with COVID-19 in the community recover sooner, prevent the need for hospital admission and ease the burden on the NHS. They are intended for use in the very early stages of infection, by people in the community who are at higher risk of complications.
There are two routes into the trial:
• Local people can log on to the national website - www.panoramictrial.org - to join the study if they are aged 50 and over, or between 18 to 49 years with underlying health conditions that make them clinically more vulnerable.
• Those who have received a positive PCR may also be contacted by the trial team or a local healthcare professional to consider enrolling in the study.
All participants will need to have had a positive COVID-19 test and be within five days of the onset of symptoms.
A total of 10,600 volunteers are needed nationally, to take part in the study. Half of the participants will be randomly allocated to receive the antiviral treatment plus standard care, while the other half will receive standard care alone.
Participants do not need to visit a clinic or hospital to take part and will keep a daily diary for 28 days through the PANORAMIC website or receive a phone call from the trial team on days 7, 14 and 28 to speak about their symptoms and any NHS care they have needed.
Tom Spencer, Research & Development Manager at Chesterfield Royal Hospital, said: “This is a great accolade for the region. The team have worked closely in recent years to increase research across our GP sites at Royal Primary Care.
“Being selected as one of the first hubs in the UK for this important study is great recognition for the work we have put in to date and ultimately is a real positive option for our patients and local population.”
The Trust is also involved in delivering the national RECOVERY trial, which was the trial that demonstrated dexamethasone is an effective treatment option for the virus in hospitalised patients.
Dr Adrian Beltran-Martinez, Research Lead GP, at Royal Primary Care, Chesterfield, said: “Research has already enabled us to make enormous strides in our efforts to reduce the spread of COVID-19 and improve the outcomes of people infected. It is hoped that these new antiviral treatments could be another important tool for the NHS.
“I would urge anyone in Derbyshire who receives a positive PCR test to consider stepping forward to take part in this study, if you meet the criteria. By doing so you will be playing a vital role in helping experts find new ways to tackle the symptoms of COVID-19.”
Dr Peter Scriven, Divisional Director of Royal Primary Care, said: “When taken in the earliest stages of infection, these ground-breaking, purpose-designed, COVID-19 antiviral treatments hold the potential to greatly improve outcomes for patients most at risk from the disease. As orally-administered treatments, designed to be taken at home soon after the onset of symptoms, the drugs work by disrupting and preventing the virus from multiplying inside the body.”
The NIHR is partnering with the University of Oxford, several other UK universities, GPs and the NHS to help deliver this national priority trial at pace and scale across the United Kingdom.
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